© Copyright 2017 Juvent

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


     Provide a Multifaceted Approach to Bone Maintenance and Strength*
     Provide Foundational Bone Support with Choline-Stabilized Orthosilicic Acid (ch-OSA®)*
     Support Bone Collagen Formation, Bone Mineral Density, and Bone Calcium Binding Sites*
     Provide a Complementary Combination of Micronutrients*

HydroxyBMD AM is our calcium/MCHC-free formula that combines Bonolive® olive extract with ch-OSA, D3, and MK-7 to provide bone and cardiovascular support.*

Bonolive Olive Leaf Extract
Bonolive is a pharmaceutical-grade olive leaf extract that features a unique polyphenol complex (40% polyphenols), including oleuropein. This proprietary olive extract preparation is fully water-soluble, which makes its oral bioavailability superior. Historical and traditional use as well as clinical testing and toxicological assessment confirm the safety of its oral consumption.[1,2]

Stem cell research has shown that olive polyphenol bioactivity is associated with increased osteoblast formation, increased extracellular matrix mineralization, and overall bone maintenance.[3] Five preclinical studies in a well-established rat model for bone health demonstrated that olive polyphenols exert protective effects on the formation and maintenance of bone.[4,5] In addition, a randomized, double-blind, placebo-controlled clinical study provided strong support for Boneolive promoted a statistically significant improvement (32% increase) in levels of the bone formation marker osteocalcin over a 12-month period. Furthermore, DEXA scan results suggested that Bonolive supplementation positively supported BMD at the lumbar spine and the femur neck compared to a placebo.[6] The treatment group also experienced reduced adipocyte formation and a positive effect on lipid metabolism (i.e., cholesterol and triglycerides), confirming Boneolive’s double mode of action: 

To positively influence bone health and cardiovascular health.

HydroxyBMD AM Supplement Facts










Directions:
Take one packet daily in the morning.

(Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Consider total vitamin K intake (food + supplements) if you are taking blood-thinning medication. Do not use if tamper seal is damaged.)

Does not contain: Wheat, gluten, yeast, soy protein, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organism (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Storage: Keep tightly closed in a cool, dry place out of reach of children.


     Supports Bone Metabolism*
     Supports Bone Strength*
     Provides Micronutrients for Utilization in Bone Production and Structure*

Featuring

A WINNING FORMULA: 

Your Doctor's Guidance

Your Micro-Nutrients

Your Micro-Impact

PLUS

The Benefits of

Bonolive® is a trademark of BioActor.

Order Our Bundle and Save $350

- BonOlive provides powerful antioxidant support at cellular level*
- BonOlive helps support cardiovascular health*
- BonOlive may improve bone health*
- Non-GMO, Soy Free, Gluten Free, Vegan

Olive fruits provide essential components of the Mediterranean diet known for being associated with improved cardiovascular and overall health.[1,2] Historically, olive leaves have been used in folk remedies to improve digestive, cardiovascular, and skin conditions. One of the key components in BONOLIVE is oleuropein, a powerful phytonutrient unique to the olive tree. At a cellular level oleuropein promotes bone formation by inhibiting adipocyte differentiation, and enhancing differentiation into osteoblasts.[3,4,5,6]

In the past years, interest in natural antioxidants as bioactive components of food has been rising. The positive effects of diets rich in fruits, vegetables and olive oil on overall health have been attributed partly to certain compound as phenolic compounds.[*3] Oleuropein gives the bitterness taste of olive oil but is also the major phenolic compound in olive leaves that has been studied for its antioxidant activity involving in promising results with respect to its effect on human health.[*3,5,7] The daily consumption of olive oil in population that follow the Mediterranean diet, provides enough oleuropein in the body to supply protection against free radicals and lipid peroxidation in humans.[*8] The antioxidant abilities, the scavenging abilities, the chemistry and pharmacological aspects of oleuropein have been widely studied and are well known.[7,9,10]

provides powerful antioxidant support at cellular level

For decades, the Mediterranean diet has been considered to be one of the most healthy. In the 1960's, scientific works started to observe the positive effect of overall cardiovascular health in population that followed the Mediterranean diet.[*11] Olive oil is the most popular dietary liquid from the Mediterranean diet and much of the evidence of its beneficial health is attributed to oleuropein, the major phenolic in olive leaves.[12,13,14,15,16]

Epidemiological studies have shown that the incidence of bone loss was lower in the Mediterranean basin where traditional Mediterranean diet that include consumption of olive oil is widely consumed by the population.[17] Moreover, experimental models have been able to show that oleuropein is the phenolic compound from olive leaves involved in hindering, the loss of bone mass suggesting its possible key role in improving bone health.[*18,19]

helps support cardiovascular health*

may improve bone health*

®

®

®

®

Naturally Supporting Healthy & Balanced Bone Metabolism

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Clinically Proven

BonOlive is a clinically proven bone health supplement. A randomized, double-blind, placebo-controlled study proved that BonOlive has significant effects on stimulation of bone building cells (osteoblasts) and blood liquid profiles.

The figure illustrates the 32% increase in osteocalcin levels over 12 months, which was statistically significant and indicates an increase in osteoblast activity (bone formation). Also blood liquid markers improved. A significant treatment effect was observed for total cholesterol LDL-cholesterol and triglyceride levels. Finally, DEXA scans showed subjects taking BonOlive displayed a protection of bone mineral density at the femur neck compared to those taking placebo.

Superior Bioavailability

Furthermore, results of a pharmacokinetic study shown the intake of BonOlive leads to an excellent bioavailability of bioactive metabolites in the target population for use of BonOlive.

ALBION is the world leader and innovator in mineral amino acid chelate nutrition. Since its establishment in 1956, Albion has sought to manufacture highly bioavailable nutritional mineral forms and to understand their function and prove their effectiveness through third party research and clinical studies. This deep understanding and continued research has kept Albion on the leading edge of product development and application. With two sales divisions under the corporate umbrella, Albion serves the plant and human nutrition industries worldwide.

With the corporate offices located in Clearfield, Utah, Albion has an affiliated distribution network that reaches into nearly 100 countries. The organic mineral compounds—such as mineral amino acid chelates, specialized mineral salts, and mineral complexes—manufactured by Albion can be found in a wide variety of products that nourish and enhance life. Some of these products include foliar applied fertilizers for high value crops and pharmaceutical grade chelates used in mineral supplements and food for humans. Only Albion has this scope of application and continued innovation in mineral nutrition for life.

Backed by sound science and over 100 patents from manufacturing processes to food applications, Albion is your trusted source for safe, proven, effective, organic minerals.

Six Stage Chelates:

Chelated Minerals for Human Nutrition

Albion® is the leading supplier of chelated minerals as raw materials for inclusion in premier human nutrition products. At Albion, science and patented technology have been combined to create an organic molecule in a form the body can readily assimilate. These special organic forms of inorganic mineral elements are mineral amino acid chelates. Albion’s amino acid chelates used in mineral supplements and food fortification provide complete organic mineral nutrition, giving your customers the greatest chance to absorb the minerals for their best biological advantage.

Our Science Makes all the Difference

Long known as The Mineral People™, Albion is in the business of making very specific molecules backed by sound science and research. We’ve been making chelated minerals for more than 50 years. Albion is renowned for its science and recognized as a world leader and innovator in mineral amino acid chelate nutrition. Years of extensive research, clinical analysis, third-party critiques, and careful laboratory manufacturing enable Albion to produce a fully reacted and highly effective chelate. In fact, we are the only chelate manufacturer that can scientifically prove our molecular structure! By identifying a unique "fingerprint" for each molecule we develop, our customers know Albion minerals are what we say they are: true mineral amino acid chelates.

Albion is a privately owned company that has been granted more than 100 patents in the field of mineral nutrition. Albion’s team of distinguished scientists includes published researchers who have addressed scientific congresses throughout the world. We innovated the Albion TRAACS® range of organic mineral products containing chelated macro and trace minerals designed to provide optimal health, absorption, quality, and return on investment.

Many companies around the world incorporate Albion’s amino acid chelates in their own product brands. These include dietary supplement companies, pharma companies, and food & beverage companies.

Whether you’ve just been diagnosed with low bone mineral density, you believe that you are at risk, or you are several years into your bone health regimen and want to make sure that you are doing your best: Juvent has you covered.  

You see we are a company committed to being a key partner in your lifelong bone health journey. For over 25 years the name Juvent has represented the world’s safest and most effective bone health exercise technology. Our valued customers have asked us to offer an equally impressive supplement. After years of research and sourcing we believe we have the best:

Let me introduce you to the HydroxyBMD System. This System is unique in many ways and allows you and your physician the flexibility to match YOUR needs. It's not a one size fits all solution that is so often your only choice.

What makes this Professional Quality 

Bone Health System so Unique?

                 a pharmaceutical-grade olive leaf extract which improved bone and cardiovascular health in clinical studies[1-19].

A Calcium Free (CF) option. A chelated, natural calcium/mineral add-on allowing you and your physician to decide how much calcium and minerals are right for you.

A New Zealand microcrystalline hydroxyapatite concentrate
(MCHC): a complex crystalline compound containing numerous
essential trace elements that naturally occur in healthy bone.

Patented 6 Stage Chelated Minerals for maximum
bioavailability and less likely to cause discomfort.

ch-OSA, a patented bioactive form of silicon that assures
maximum absorption.

These are just some of the highlights of this powerful system. But equally as important is the assurance that only the highest quality ingredients have been used 
and what is on the label is what is in the product.

We believe that HydroxyBMD coupled with our Micro-Impact Platform will be key to solve the bone health puzzle. 

®

HydroxyBMD PM is a well-researched, standardized extract from one of the world’s safest premium sources of bone - free-range New Zealand cattle. 
HydroxyBMD PM contains microcrystalline hydroxyapatite concentrate (MCHC), a complex crystalline compound containing calcium, phosphorus, bioactive growth factors, type I collagen, amino acids, glycosaminoglycans, and a broad range of essential trace elements that naturally comprise healthy bone.*

HydroxyBMD PM delivers 500 mg of MCHC per capsule along with additional calcium and magnesium in the form of highly absorbable Albion® minerals. Vitamin D, in the form of cholecalciferol, supports intestinal calcium absorption and homeostasis in the body and completes the comprehensiveness of this bone-support formula.*

Clinical Trials suggested that HydroxyBMD PM supplementation was well-tolerated and yielded a positive outcome for dental status, bone integrity, and healthy bone metabolism.[1.2] A randomized, controlled study indicated that the addition of HydroxyBMD PM to exogenously administered hormones provided statistically significant support (4.7%, P<0.1) to vertebral bone mass.[2] Another study of 60 subjects suggested that bone mass was maintained while on HydroxyBMD PM.[3]

HydroxyBMD PM Supplement Facts










Directions:
Take four capsules with your meal daily in the afternoon/evening.

(Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged. The labeling on this product does not comply with California’s Proposition 65. Therefore, this product may not be sold in California.)

Does not contain: Wheat, gluten, yeast, soy protein, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organism (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Storage: Keep tightly closed in a cool, dry place out of reach of children.






*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

SOLVE THE BONE HEALTH PUZZLE 

INTRODUCING

JUVENT Micro-Impact Platform

Get Your HydroxyBMD System Here

Scientific References BONOLIVE
1. Covas M, Ruiz-Gutierrez V., De La Torre R, et al. Minor Components of Olive Oil: Evidence to Date of Health Benefits in Humans.  Nutr Rev. 2006;64:20-30.
2. Buckland G. and Gonzales CA. The role of olive oil in disease prevention: a focus on the recent epidemiological evidence from cohort studies and dietary intervention trials. Brit J Nutr. 2015;113:S94-S101.
3. Benavente-Garcia O, Castillo J. Lorente J et al. Antioxidant activity of phenolics extracted from Olea europaea L. leaves. Food Chem. 2000;68:457-462.
4. Ghedira K. L’olivier. Phytotherapie. 2008;6:83-89.
5. Barbaro B, Toietta G, Maggio R et al. Effects of the olive-derived polyphenol oleuropein on human health. Int J Mol Sci. 2014;15:18508-15524.
6. Ben Salem M, Affes H, Ksouda K, et al. Pharmacological Activities of Olea europaea Leaves. J Food Processing and Preservation. 2015;39:3128-3136.
7. Wichers HJ, Espin JC and Soler-Rivas C. Oleuropein and related compounds. J Sci Food and Agric. 2000;80:1013-1023.
8. Perona JS, Cabello-Moruno R and Ruiz-Gutierrez V. The role of virgin olive oil components in the modulation of endothelial function. J Nutr Biochem. 2006;17:429-445.
9. Tuck KL and Hayball PJ. Major phenolic compounds in olive oil: metabolism and health effects. J Nutr Biochem. 2002;13:636-644.
10.Tripoli E, Giammanco M, Tabacchi G et al. The phenolic compounds of olive oil: structure, biological activity and beneficial effects on human health. Nutr Res Rev. 2005;18:98-112.
11.Psaltopoulou T, Naska A, Orfanos P, and al. Olive oil, the Mediterranean diet, and arterial blood pressure: the Greek European Prospective Investigation into Cancer and Nutrition (EPIC) study. The American journal of clinical nutrition. 2004;80:1012.
12.Covas MI. Olive oil and the cardiovascular system. Pharmacol Res. 2007;55:175-186.
13.Zacharias E. The Mediterranean Diet: A Clinician’s Guide for Patient Care. Publisher: Springer New York. 2012.
14.Waterman E. and Lockwood B. Active components and clinical applications of olive oil. Alternative medicine review: J Clin Ther. 2007;12:331.
15.Omar SH. Oleuropein in olive and its pharmacological effects. Scientia pharmaceutica. 2010;78:133-154.
16.Preedy VR, Watson RR. Olives and Olive Oil in Health and Disease Prevention. 1st ed. Amsterdam; Boston: Elsevier/Academic Press; 2010;2013.
17.Santiago-Mora R, Casado-Diaz A. De Castro MD et al. Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone marrow. Osteoporosis Int. 2011;22:675-684.
18.Puel C, Mathey J, Agalias A et al. Dose-response study of effect of oleuropein, an olive oil polyphenol in an ovariextomy/inflammation experimental model of bone loss in the rat. Clin Nutr. 2006;25:859-868.
19.Garcis-Martinez O, Rivas A, Ramos-Torrecillas J. et l. The effect of olive oil on osteoporosis prevention. Int J Food Sci nutr. 2014;65:834-840.

Scientific References for HydroxyBMD AM's Formulation
1. Filip R, Possemiers S, Heyerick A, et al. Twelve-month consumption of a polyphenol extract from olive in a double blind, randomized trial increases serum total osteocalcin levels and improves serum lipid profiles in postmenopausal women with             osteopenia. J Nutr Health Aging. 2015 Jan; 19(1):77-86. [PMID:9483660] 
2. Clewell AE, Beres E, Vertesi A., et al. A comprehensive toxicological safety assessment of an extract of Olea Europea L. leaves (BonoliveTM). Int J Toxicol. 2015 Dec 10. pii: 1091581815619764. Epub ahead of print.[PMID: 26658007 
3. Santiago-Mora R, Casado-Diaz A, De Castro MD, et al. Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone narrow. Osteoporos Int. 2011 Feb;22(2):675-84. [PMID: 20495905] 4. Puel C, Mardon J, Agalias A, et al. Major phenolic compounds in olive oil modulate bone loss in an ovariectomy/inflammation experimental model. J Agric Food Chem. 2008 Oct. 22;56(20):9417-22. [PMID: 18800805] 
5. Puel C, Mahey J, Agalias A, et al. Dose-response study of effect of oleuropein, an olive oil polyphenol, in an ovariectomy/inflammation experimental model of bone loss in the rat. Clin Nutr. 2006 Oct;25(5):859-68.[PMID: 16740345]. 
6. Puel C, Quintin A, Angalias A, et al. Olive oil and its main phenolic micronutrient (oleuropein) prevent inflammation-induced bone loss in the ovariectomised rat. Br J Nutr. 2004 Jul;92(1):119-27. [PMID: 15230995] 
7. Puel C, Mardon J, Kati-Coulibaly S, et al. Black Luques olives prevented bone loss caused by ovariectomy and talc granulomatosis in rats. Br J Nutr. 2007 May;97(50:1012-20. [PMID: 17408530] 
8. Hagiwara K, Goto T, Araki M, et al. Olive polyphenol hydroxytyrosol prevents bone loss. Eur J Pharmasol. 2011 Jul 15;662(1-3):78-84. [PMID: 21539839]

Scientific References for HydroxyBMD PM's Formulation
1. Khadzhiev A, Rachev E, Katsarova M, et al. The results of a clinical trial of the preparation ('HydroxyBMD PM') [in Bulgarian]. Akush Ginekol (Sofiia). 1990;29(4):85-7. [PMID: 2176437] 
2. Castelo-Branco C, Martinez de Osaba MJ, Pons F, et al. Ossein-hydroxyapatite compounds for preventing postmenopausal bone loss. Coadjuvant use with hormone replacement therapy. J Reprod Med. 1999 Mar;44(3):241-6. [PMID: 10202741] 
3. Castelo-Branco C, Pons F, Vicente JJ, et al. Preventing postmenopausal bone loss with ossein-hydroxyapatite compounds. Results of a two-year, prospective trial. J Reprod Med. 1999 Jul;44(7):601-5. [PMID: 10442322]

Discover the many benefits of Our Unique Ingredients

All these Amazing Ingredients come together in HydroxyBMD

In the Morning:

In the Evening:

Get Your HydroxyBMD System Here

Interview with Sam Possemiers, PhD Research Director, BioActor (Graduated from Ghent University)